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Reprogramming to recover youthful epigenetic information and restore vision

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Researchers at Harvard Medical School have found a way to reverse the aging process and restore eyesight - at least in mice. Aging is an inevitable part of life that most people live to experience. Although the longevity of humans has notably improved since we evolved 200,000 years ago, the multidimensional nature of aging has prevented us from fully understanding this. Expression of three Yamanaka transcription factors in mouse retinal ganglion cells restores youthful DNA methylation patterns, promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice, suggesting that mammalian tissues retain a record of youthful epigenetic information that can be accessed to improve tissue function. Reprogramming to recover youthful epigenetic information and restore vision Gene editing restore vision in lab mice, raise hope of reversal of aging. First time such thing succeed in. 2020. 12. 2. · Comment of this article: Sight restored by turning back the epigenetic clock. Comment of this article: Reversal of biological clock restores vision in old mice. Reprogramming to recover youthful epigenetic information and restore vision. Yuancheng Lu,. The company's proprietary technology, epigenetic reprogramming of age (ERA), restores the youthful functionality of targeted cells while maintaining cell type integrity. Potential targets include ocular surface disease, corneal disease, age-related macular degeneration (AMD), and glaucoma. 2020. 12. 3. · Harvard Medical School (HMS) scientists have restored vision in mice by turning back the clock on aged cells in the retina to recapture youthful gene function. In addition to resetting the cells. The beneficial effects of OSK-induced reprogramming in axon regeneration and vision require the DNA demethylases TET1 and TET2. These data indicate that mammalian tissues retain a record of youthful epigenetic information-encoded in part by DNA methylation-that can be accessed to improve tissue function and promote regeneration in vivo. Nature. December 3, 2020. Neurons in the eyes of mice can be reprogrammed to a more youthful state in which they re-acquire the ability to regenerate and restore vision, a study in Nature reports. The study sheds light on the mechanisms of ageing, and identifies new potential therapeutic targets for age-related neuronal diseases such as glaucoma.

2 days ago · Information theory of aging. David Sinclair of Harvard Medical School has theorized that progressive loss of youthful epigenetic information not only is associated with aging, but. . 2020. 12. 18. · Harvard Stem Cell Institute (HSCI) scientists are part of a team that has successfully restored vision in mice by turning back the clock in aged eye cells in the retina to. 2020. 12. 18. · Harvard Stem Cell Institute (HSCI) scientists are part of a team that has successfully restored vision in mice by turning back the clock in aged eye cells in the retina to recapture youthful gene function. The team’s work, published in the journal Nature, is the first demonstration that it may be possible to safely reprogram complex tissues. Reprogramming to recover youthful epigenetic information and restore vision Nature December 3, 2020 Ageing is a degenerative process that leads to tissue dysfunction and death. The clear thing is that epigenetic rejuvenation by cyclic partial reprogramming or alternative non- reprogramming methods holds the key to understanding the epigenome's mechanism that drives the aging process and arresting or even reversing organismal aging. Takeaways: Reprogramming strategies may be accomplished both in vitro and in vivo. 2020. 12. 2. · “Reprogramming to recover youthful epigenetic information and restore vision: https://t.co/xj2g63KsYF”. (Cancelled)Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 Dec;588(7836):124-129. Add More Speakers (Optional) No 2nd Speaker/Honorific 2nd Speaker Affiliation.

2020. 12. 2. · “Reprogramming to recover youthful epigenetic information and restore vision: https://t.co/xj2g63KsYF”. in RGCs after axon and vision loss (but before the RGCs died) fully restored vision in these animals. The same was true for wild-type old mice: OSK allowed old mice to regain youthful eyesight. Why might reprogramming old RGCs to a younger state promote regeneration and restore vision? An emerging model in the field. 2020. 12. 3. · Harvard Medical School (HMS) scientists have restored vision in mice by turning back the clock on aged cells in the retina to recapture youthful gene function. In addition to resetting the cells. The beneficial effects of OSK-induced reprogramming in axon regeneration and vision require the DNA demethylases TET1 and TET2. These data indicate that mammalian tissues retain a record of youthful epigenetic information—encoded in part by DNA methylation—that can be accessed to improve tissue function and promote regeneration in vivo.". Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury. Ji B, Case LC, Liu K, Shao Z, Lee X, Yang Z, Wang J, Tian T, Shulga-Morskaya S, Scott M, He Z, Relton JK, Mi S. Mol Cell Neurosci 2008;39(2):258-267. Epigenetic reprogramming is a new form of gene therapy that can reverse the age of cells in mice, restoring youth to their transcriptome and methylome. Importantly, this rejuvenating effect can allow the retina to recover functions that were lost with aging, such as axon regeneration and sensory perception. The beneficial effects of OSK-induced reprogramming in axon regeneration and vision require the DNA demethylases TET1 and TET2. These data indicate that mammalian tissues retain a record of youthful epigenetic information—encoded in part by DNA methylation—that can be accessed to improve tissue function and promote regeneration in vivo. Lu, Y. et al. (2020) Reprogramming to recover youthful epigenetic information and restore vision.Nature 588, 124-129 (2020). Wendell P. et al. (2020) A cost-effective approach to DNA methylation detection by Methyl Sensitive DArT sequencing. PLoS ONE 15(6): e0233800.

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